Keratinocytes derived from late-onset-psoriasis skin do not impair Langerhans cell migration
نویسندگان
چکیده
منابع مشابه
Impaired Langerhans cell migration in psoriasis
We have examined whether psoriasis is associated with systemic effects on epidermal Langerhans cell (LC) function and, specifically, the migration of LCs from the skin. Compared with normal skin, the frequency and morphology of epidermal LCs in uninvolved skin from patients with psoriasis was normal. However, mobilization of these cells in response to stimuli that normally induce migration (che...
متن کاملNo impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis
BACKGROUND Migration of epidermal Langerhans cells (LCs) in response to the cytokines interleukin (IL)-1β and tumour necrosis factor (TNF)-α is impaired in uninvolved skin of patients with early-onset psoriasis. AIM To investigate whether this impairment is a reflection of a systemic defect in dendritic cells (DCs), using an established model of monocyte-derived LC-like cells (mLCs). METHOD...
متن کاملTreatment-Related Restoration of Langerhans Cell Migration in Psoriasis
effect on patient’s life’’ (Hongbo et al., 2005). Imagine you want to evaluate the effect of a treatment on the patient’s quality of life that is extremely affected by a dermatological disease (DLQI scores between 21 and 30). You define success when the score after the treatment is between 11 and 20, because it is considered clinically relevant. After treatment, scores of one patient decrease f...
متن کاملSolitary, late-onset, self-healing Langerhans cell histiocytosis.
© 2011 The Authors. doi: 10.2340/00015555-0990 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 “Self-healing” Langerhans’ cell histiocytosis (LCH), first reported by Hashimoto & Pritzker in 1973 (1), is a rare primary skin disorder that presents at birth or just after birth. It can be categorized based on the involvement of solitary or multiple sites and can be further cla...
متن کاملCorticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development.
Corticosteroids (CS) have been shown to exert strong inhibitory effects on dendritic cell (DC) differentiation and function. Those studies were mostly performed with monocyte-derived DC, which represents only one subpopulation from the wide variety of DC types. In the present study the effects of the CS dexamethasone and prednisolone were investigated on the differentiation of CD34(+) hemopoiet...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2018
ISSN: 0007-0963
DOI: 10.1111/bjd.16896